Publisher: Academic Press
ISSN: 0022-4804
Source: Journal of Surgical Research, Vol.62, Iss.2, 1996-05, pp. : 260-266
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
8-Amino-9-benzylguanine (8-ABG), a potent purine nucleoside phosphorylase inhibitor, was administered to dogs for 10 days following single renal transplantation. A significant prolongation of graft survival was observed in the groups treated with 100 and 150 mg kg/day of 8-ABG per os compared with the control group that was not treated with any immunosuppressant. Expression of major histocompatibility complex (MHC) class II antigens (Ag) was investigated in the normal kidney(s) and renal allografts of mongrel dogs after single renal transplantation. The 8-ABG was administered to the normal and renal allografted dogs and no detectable MHC class II Ag in the normal kidneys was found. During acute rejection, the MHC class II Ag was expressed on the renal tubular epithelium and glomerular vascular endothelium in graft kidneys. The intensity of the MHC class II Ag expression was correlated to the severity of rejection. This abnormal expression of MHC class II Ag on allograft kidney was suppressed by 8-ABG treatment. Our results suggest that MHC class II Ag expression can be induced on the renal allografts during acute rejection. This abnormal expression of MHC class II Ag may serve as a specific index for diagnosis of kidney allograft rejection. That 8-ABG can suppress abnormal expression of MHC class Ag on allografted kidney and prolong graft survival indicates that 8-ABG may provide an alternative approach for the development of a potential new immunosuppressant.
Related content
By Kırımca Feza Sarıoğlu Sülen Çamsarı Taner Kavukçu Salih
Scandinavian Journal of Urology and Nephrology, Vol. 35, Iss. 6, 2001-12 ,pp. :
By Doenecke A.
Langenbeck's Archives of Surgery, Vol. 393, Iss. 3, 2008-05 ,pp. :
By Rodrigues Fernanda de Carvalho Maria Fernanda Franchi Marcos Gandin Celene Viero Rosa
Renal Failure, Vol. 29, Iss. 1, 2007-01 ,pp. :
By Goto M. Yamaguchi Y. Matsuno K. Takata N. Makino Y. Kikuchi N. Hamaguchi H. Hisama N. Miyanari N. Mori K. Ogawa M.
Journal of Surgical Research, Vol. 60, Iss. 1, 1996-01 ,pp. :