Suppression of Interleukin 2 Biosynthesis by Three Modes of Oxidative Cellular Stress: Selective Prevention by N-Acetyl Cysteine

Author: Flescher E.   Fingrut O.  

Publisher: Academic Press

ISSN: 1043-4666

Source: Cytokine, Vol.12, Iss.5, 2000-05, pp. : 495-498

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Abstract

Acute stress induced by reagent hydrogen peroxide suppressed interleukin (IL-)2 biosynthesis in a dose-dependent fashion, reaching almost complete abolishment at 200 μM. Cells exposed to longitudinal oxidative stress and irradiation did not exhibit complete suppression of IL-2 biosynthesis, probably because intensities high enough to achieve such response would be lethal. These results suggest that suppression of IL-2 biosynthesis is a sensitive measure of acute oxidative stress. N-acetyl cysteine (NAC) prevented oxidative stress-induced suppression of IL-2 biosynthesis, except for that induced by acute stress at 100 μM and above. NAC was very efficient in preventing longitudinal and irradiation-induced stresses. Therefore, NAC appears to be a promising candidate for providing defence to individuals exposed to environmental conditions in which reactive oxygen intermediates are generated.

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