Author: Späth-Schwalbe E. Lange T. Perras B. Lorenz Fehm H. Born J.
Publisher: Academic Press
ISSN: 1043-4666
Source: Cytokine, Vol.12, Iss.5, 2000-05, pp. : 518-521
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Abstract
We investigated the effects of two low doses of interferon-α (IFN-α) on nocturnal sleep in 18 healthy men by means of polysomnographic sleep recordings. At 1900h, human recombinant IFN-α (1000 or 10 000 U/kg body weight) or placebo was administered subcutaneously. Between 2300h and 0700h subjects were allowed to sleep. In general effects were stronger at the dose of 10 000 than 1000 U/kg body weight of IFN-α. Although, after IFN-α subjects experienced increased fatigue, the cytokine impaired the quality of nocturnal sleep. The higher dose of IFN-α suppressed slow wave sleep (17.8±2.0% vs 25.2±2.6% following placebo,
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