Author： Letourneux Y. Bourass J. Boucrot P. Elkihel L. Petit J.Y.
Publisher： Academic Press
ISSN： 1043-6618
Source： Pharmacological Research, Vol.35, Iss.1, 1997-01, pp. : 73-78
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
At concentrations 1-20 gm M in culture medium of rat peritoneal macrophages which were stimulated with ionophore A23187, the phospholipid analogues 1-decyl-2-octyl-glycero- phosphocholine and 1-dodecyl-2-octanamido-2-deoxy glycerophosphocholine were found more potent inhibitors than 1-octyl-2-octylthio-2-deoxy glycerophosphocholine to lower the phospholipase A 2 activities. The inhibitory effect was measured by [ 3 H] eicosatetraenoic acid ([ 3 H]20:4) release in macrophages and extracellular fluids and synthesis of [ 3 H] eicosanoids after incubation of macrophages with traces of the molecular species of lecithin 1-octadecanoyl-2-[ 3 H] eicosatetraenoyl glycerophosphocholine. The three phospholipid analogues developed higher inhibitory effects than mepacrine, dexamethasone or bromophenacyl bromide, at corresponding concentrations in medium.
Related content
By Wood L. Leese1 M.P. Leblond1 B. Woo1 L.W.L. Ganeshapillai1 D. Purohit2 A. Reed2 M.J. Potter1 B.V.L. Packham G.
Anti-Cancer Drug Design, Vol. 16, Iss. 4, 2001-08 ,pp. :
Access to resources
Recommend
By Binisti C. Assogba L. Touboul E. Mounier C. Huet J. Ombetta J.-E. Dong C.Z. Redeuilh C. Heymans F. Godfroid J.-J.
European Journal of Medicinal Chemistry, Vol. 36, Iss. 10, 2001-10 ,pp. :
Capsaicin and Its Analogues: Structure-Activity Relationship Study
Current Medicinal Chemistry, Vol. 20, Iss. 21, 2013-07 ,pp. :
By Fischer M.J.E. Paulussen J.J.C. Tollenaere J.P. De Mol N.J. Janssen L.H.M.
European Journal of Pharmacology, Vol. 350, Iss. 2, 1998-06 ,pp. :