ocimum Sanctum Leaf Extract in the Regulation of Thyroid Function in the Male Mouse

ISSN： 1043-6618

Source： Pharmacological Research, Vol.38, Iss.2, 1998-07, pp. : 107-110

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Abstract

The effects of Ocimum sanctum leaf extract on the changes in the concentrations of serum triiodothyronine (T₃), thyroxine (T₄) and serum cholesterol; in the activities of hepatic glucose-6-phosphatase (G-6-P), superoxide dismutase (SOD) and catalase (CAT); hepatic lipid peroxidation (LPO) and on the changes in the weight of the sex organs were investigated. While the plant extract at the dose of 0.5 g kg^-1 body wt. for 15 days significantly decreased serum T₄ concentrations, hepatic LPO and G-6-P activity, the activities of endogenous antioxidant enzymes, SOD and CAT were increased by the drug. However, no marked changes were observed in serum T₃ level, T₃/T₄ ratio and in the concentration of serum cholesterol. It appears that Ocimum sanctum leaf extract is antithyroidic as well as antioxidative in nature.