Author： Baldridge J.R. Crane R.T.
Publisher： Academic Press
ISSN： 1046-2023
Source： Methods, Vol.19, Iss.1, 1999-09, pp. : 103-107
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Many of the latest trends in vaccine development are dependent on immunological adjuvants that mediate and promote a wide variety of immune responses. One promising adjuvant candidate, monophosphoryl lipid A (MPL) immunostimulant, is being investigated with many of these new vaccine approaches in either preclinical or clinical trials. This is possible because different vehicle formulations can significantly influence the type of immunological response MPL promotes. Procedures are provided for formulating MPL in an aqueous vehicle or an oil-in-water emulsion. These two MPL formulations can be beneficial for most vaccine approaches being investigated today.
Related content
Access to resources
Recommend
Cytoplasmic signalling domains: the next generation
By Bork P. Schultz J. Ponting C.P.
Trends in Biochemical Sciences, Vol. 22, Iss. 8, 1997-08 ,pp. :