Author： Garcia C.R.S. Takeuschi M. Yoshioka K. Miyamoto H.
Publisher： Academic Press
ISSN： 1047-8477
Source： Journal of Structural Biology, Vol.119, Iss.2, 1997-07, pp. : 92-98
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Abstract
Atomic force microscopy was used to image the membrane cytoskeleton network of normal and P. falciparum -infected ghosts. The membrane cytoskeleton network was examined in air-dried ghost preparations from normal and infected cells. We found that the spectrin network was changed in infected ghosts. The thickness of the normal red cell membrane was about 15.05 ± 2.27 nm, while the thickness of the P. falciparum -infected membrane was found to be 22.97 ± 3.84 nm. The ghost containing ring stage parasites exhibited areas of particle-like protrusions ranging in size from 0.2 to 0.7 mum. The surface of the P. falciparum parasite was also imaged in air-dried samples, showing the existence of a large protrusion extending from the parasite surface.
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