Author: Erkkilä A.T. Lindi V. Lehto S. Laakso M. Uusitupa M.I.J.
Publisher: Academic Press
ISSN: 1096-7192
Source: Molecular Genetics and Metabolism, Vol.75, Iss.3, 2002-03, pp. : 260-264
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Leucine 7 (Leu7) to proline 7 (Pro7) substitution in the neuropeptide Y (NPY) gene has been associated with higher serum total and low-density lipoprotein (LDL) cholesterol levels, particularly in obese subjects. We investigated the frequency of the Pro7 allele and the association of the polymorphism with serum lipid levels in patients with coronary heart disease (CHD). A total of 414 CHD patients (mean age 61 years, range 33–74) participated in the cross-sectional EUROASPIRE study. Of the subjects 39% used lipid-lowering drugs. The frequency of the Pro7 allele in CHD patients (0.082) did not differ from that in control subjects (0.071). The mean (±SD) serum total cholesterol concentration was higher in women with the Pro7 allele (7.57 ± 0.57 mmol/L,
Related content
By Hornick P. Smith J. Pomerance A. Banner N. Mitchell A. Rose M. Yacoub M.
Transplantation Proceedings, Vol. 29, Iss. 1, 1997-02 ,pp. :
By Paniagua M.J. Crespo-Leiro M.G. De la Fuente L. Tabuyo T. Mosquera I. Canizares A. Naya C. Farina P. Juffe A. Castro-Beiras A.
Transplantation Proceedings, Vol. 34, Iss. 1, 2002-02 ,pp. :