Author： Plopper G.E. Huff J.L. Rust W.L. Schwartz M.A. Quaranta V.
Publisher： Academic Press
ISSN： 1522-4724
Source： Molecular Cell Biology Research Communications, Vol.4, Iss.2, 2000-08, pp. : 129-135
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Abstract
The β1 integrin-stimulating antibody TS2/16 induces cAMP-dependent migration of MCF-10A breast cells on the extracellular matrix protein laminin-5. TS2/16 stimulates a rise in intracellular cAMP within 20 min after plating. Pertussis toxin, which inhibits both antibody-induced migration and cAMP accumulation, targets the Gαi3 subunit of heterotrimeric G proteins in these cells, suggesting that Gαi3 may link integrin activation and migration via a cAMP signaling pathway.
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