Author： Pacella Claudio Valle Dario Bizzarri Giancarlo Pacella Sara Brunetti Maurizio Maritati Raffaele Osborn John Stasi Roberto
Publisher： Informa Healthcare
ISSN： 0284-186X
Source： Acta Oncologica, Vol.45, Iss.1, 2006-02, pp. : 77-83
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Abstract
We prospectively evaluated the safety, local tumor control, and impact on survival parameters of percutaneous laser ablation (PLA) in patients with colorectal liver metastases not amenable to surgical resection. The study included 44 individuals with 75 unresectable liver metastases and no known extrahepatic disease. The median number of metastases treated for each patient was one, with a range of 1–4. Metastases had a median diameter of 3.4?cm (range 0.5–9?cm), and a median volume of 16.8?cm 3 (range 0.4–176.4?cm 3 ). All patients also received systemic chemotherapy with modalities that differed according to the type of response to PLA. After treatment, 61% (46/75) of the tumors were ablated completely. The likelihood of achieving a complete ablation was significantly higher when metastases had a diameter
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