Expression and Functional Roles of Smad1 and BMPR-IB in Glioma Development

Author: Liu Shuang   Tian Zengmin   Yin Feng   Zhang Peng   W. Yanrui   Ding Xuefeng   Wu Haitao   Wu Yan   Peng Xiaozhong   Yuan Jiangang   Qiang Boqin   Fan Wenhong   Fan Ming  

Publisher: Informa Healthcare

ISSN: 0735-7907

Source: Cancer Investigation, Vol.27, Iss.7, 2009-08, pp. : 734-740

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Here we report the negative correlation of phosphorylation of Smad1 and BMPR-IB expression with the development of human glioma. Western blot analysis showed that expression of both phospho-Smad1/5/8 and BMPR-IB were decreased in malignant glioma tissues compared with normal brain tissues. Kaplan-Meier survival curves revealed that lower expression ratio of phospho-Smad1/5/8 to Smad1 expression significantly correlates with poor patient survival. Transient transfection of BMPR-IB activates Smad1 signaling and induces differentiation and apoptosis of U251 and U87 glioblastoma cells. The effects could be blocked by cotransfection of Smad6. These results might provide new molecular marker and target for glioma diagnosis and therapy.

Related content