A Novel PIK3CA Hotspot Mutation in Isfahanian Breast Cancer Patients

Author： Gharbi Sedigheh   Faghihi Mehri   Tavassoli Manoochehr  

Publisher： Informa Healthcare

ISSN： 0735-7907

Source： Cancer Investigation, Vol.29, Iss.4, 2011-04, pp. : 313-317

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Somatic mutations of phosphatidylinositol 3-kinase (PI3K) catalytic subunit (PIK3CA) play an important role in tumorigenesis. Using PCR-SSCP, followed by sequencing, we examined the PIK3CA gene over the previously identified mutational hotspots in a panel of 50 breast cancer and 5 normal breast tissue, as well as 50 normal blood samples isolated from a population of Iranian patients. In the present study, the frequency of PIK3CA mutation was 14%%. However, the previously identified hotspot mutations in exons 20 were completely absent in these breast cancer samples. Instead, we found a new hotspot mutation (3 of 50 samples) in exon 20.

Related content

PIK3CA Exon 20 Mutation is Independently Associated with a Poor Prognosis in Breast Cancer Patients

By Lai Yuen-Liang  

Annals of Surgical Oncology, Vol. 15, Iss. 4, 2008-04 ,pp. : 1064-1069 (6)

Springer Publishing Company

Access to resources Recommend Favorite

PIK3CA Gene Mutations and Amplifications in Chinese Patients With Ovarian Clear Cell Carcinoma

By Jiang Gaofeng   Huang Zhixiong   Zhang Shuangling   Wang Lin  

Cancer Investigation, Vol. 31, Iss. 10, 2013-12 ,pp. : 639-644 (6)

Informa Healthcare

Access to resources Recommend Favorite

Clinical usefulness of KRAS, BRAF, and PIK3CA mutations as predictive markers of cetuximab efficacy in irinotecan- and oxaliplatin-refractory Japanese patients with metastatic colorectal cancer

By Soeda Hiroshi   Shimodaira Hideki   Watanabe Mika   Suzuki Takao   Gamoh Makio   Mori Takahiro   Komine Keigo   Iwama Noriyuki   Kato Shunsuke   Ishioka Chikashi  

International Journal of Clinical Oncology, Vol. 18, Iss. 4, 2013-08 ,pp. : 670-677 (8)

Springer Publishing Company

Access to resources Recommend Favorite

Mutation of the PIK3CA gene as a prognostic factor in patients with colorectal cancer

By                  

Oncology Letters, Vol. 10, Iss. 3, 2015-01 ,pp. : 1423-1429 (7)

Spandidos Publications

Access to resources Recommend Favorite

PIK3CA mutation and methylation influences the outcome of colorectal cancer

By                    

Oncology Letters, Vol. 3, Iss. 3, 2012-01 ,pp. : 565-570 (6)

Spandidos Publications

Access to resources Recommend Favorite