Interferon-αα Induces G1 Cell-Cycle Arrest in Renal Cell Carcinoma Cells Via Activation of Jak-Stat Signaling

Author： Shang Donghao   Yang Peiqian   Liu Yuting   Song Jian   Zhang Fengbo   Tian Ye  

Publisher： Informa Healthcare

ISSN： 0735-7907

Source： Cancer Investigation, Vol.29, Iss.5, 2011-05, pp. : 347-352

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Abstract

The purpose of this study was to clarify the mechanism of IFN-αα resistance in RCC. The effects of IFN-αα on induction of apoptosis and cell-cycle arrest were analyzed by flow cytometric analysis. Jak-Stat pathway components induced by IFN-αα was evaluated using Western blotting. The results suggested that IFN-αα caused growth inhibition of RCC cell lines via arrest in the G1 phase without inducing apoptosis. The resistance of RCC to IFN-αα was associated with the low expression of Stat1. This study indicated that the Jak-Stat pathway should be considered a primary target for improving the response of RCC to IFN-αα treatment.

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