Ectopically Expressed IBP Promotes Cell Proliferation in Oral Squamous Cell Carcinoma

Author： Jian Cong-Xiang Yang Ming-Zhen Li Peng Xiong Jian Zhang Zhu-Jun Li Chen-Jun Chen An Hu Chuan-Min Zhou Ji-Xiang Li Shu-Hui

Publisher： Informa Healthcare

ISSN： 0735-7907

Source： Cancer Investigation, Vol.30, Iss.10, 2012-12, pp. : 748-756

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Abstract

IFN regulatory factor 4 binding protein (IBP) has been shown to play an important role in the progression of malignant tumors such as breast cancer cells, but its function in oral squamous cell carcinoma (OSCC) remains unclear. We found that IBP ectopically expressed in some OSCC specimens but not in normal oral mucosa epithelium tissues. IBP expression was significantly correlated with tumor size, differentiation, clinical stage, and distant metastasis. Furthermore, IBP markedly promoted OSCC cell proliferation, shortened the G1 interval in the cell cycle, and increased cyclin D1 expression. These findings suggest that IBP may be a potential therapeutic target for OSCC.