Recent Trends in Enzymatic Conversion of Cephalosporin C to 7-Aminocephalosporanic Acid (7-ACA)

Author: Parmar Anupama   Kumar Harish   Marwaha S. S.   Kennedy J. F.  

Publisher: Informa Healthcare

ISSN: 0738-8551

Source: Critical Reviews in Biotechnology, Vol.18, Iss.1, 1998-03, pp. : 1-12

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

7-Aminocephalosporanic acid (7-ACA) is the basic building block used in the synthesis of many important semisynthetic cephalosporin antibiotics that are of current interest in the biopharmaceutical industry with a share of about 29% of the estimated worldwide antibiotic market. This article describes the important recent developments for the biosynthesis of 7-Aminocephalosporanic acid (7-ACA) from cephalosporin C using the enzymatic route. Details of purification, stability, and immobilization of the enzymes used for this biotransformation are also described.