Author： Parmar Anupama Kumar Harish Marwaha S. S. Kennedy J. F.
Publisher： Informa Healthcare
ISSN： 0738-8551
Source： Critical Reviews in Biotechnology, Vol.18, Iss.1, 1998-03, pp. : 1-12
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Abstract
7-Aminocephalosporanic acid (7-ACA) is the basic building block used in the synthesis of many important semisynthetic cephalosporin antibiotics that are of current interest in the biopharmaceutical industry with a share of about 29% of the estimated worldwide antibiotic market. This article describes the important recent developments for the biosynthesis of 7-Aminocephalosporanic acid (7-ACA) from cephalosporin C using the enzymatic route. Details of purification, stability, and immobilization of the enzymes used for this biotransformation are also described.
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