Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study)

Author： Hiuge-Shimizu Aki Kishida Ken Funahashi Tohru Ishizaka Yuko Oka Rie Okada Minoru Suzuki Shizu Takaya Norihide Nakagawa Tohru Fukui Toshiki Fukuda Hiroshi Watanabe Naoya Yoshizumi Tohru Nakamura Tadashi Matsuzawa Yuji Yamakado Minoru Shimomura Iichiro

Publisher： Informa Healthcare

ISSN： 0785-3890

Source： Annals of Medicine, Vol.44, Iss.1, 2012-02, pp. : 82-92

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Abstract

AbstractBackground. The management of cardiovascular risk factors is important for prevention of atherosclerotic cardiovascular diseases (ACVD). Visceral fat accumulation plays an important role in the clustering of cardiovascular risk factors, leading to ACVD. The present study investigated the gender- and age-specific relationship between obesity-related cardiovascular risk factor accumulation and computed tomography (CT)-measured fat distribution in a large-scale Japanese general population.Methods and results. Fat distribution was measured on CT scans in 12,443 subjects (males/females == 10,080/2,363), who underwent medical health check-up at 9 centers in Japan. The investigated obesity-related cardiovascular risk factors were hyperglycemia, dyslipidemia, and elevated blood pressure. Visceral fat area (VFA) for all males and old females showed almost symmetric distribution, while that of young females showed skewed distribution with a marked left shift. Only a small proportion of young females had large visceral fat and cardiovascular risk accumulation. The mean number of risk factors exceeded 1.0 at around 100 cm² for VFA in all groups, irrespective of gender, age (cut-off age 55), and BMI (cut-off BMI 25 kg/m²).Conclusions. In this large-scale Japan-wide general population study, an absolute VFA value of about 100 cm² equated with obesity-related cardiovascular risk factor accumulation, irrespective of gender, age, and BMI.Clinical trial registration information. https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function==brows&action==brows&type==summary&recptno==R000002780&language==E.