Author： Sui Hui Wang Wen Wang Pei Liu Li
Publisher： Informa Healthcare
ISSN： 0803-7051
Source： Blood Pressure, Vol.14, Iss.6, 2005-12, pp. : 366-372
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Abstract
Background: To investigate whether extrinsic antioxidant seleno-glutathione peroxidase mimic ebselen (PZ51) can protect endothelium and vascular structure of stroke-prone spontaneously hypertensive rats (SHRsp) during the chronic process of hypertension. Methods: Twenty-two 8-week-old SHRsp were randomized into a PZ51 group and a control group, and administered by gavage for 6 weeks. We examined the level of nitric oxide (NO) and malonaldehyde (MDA) in plasma. The intima-media thickness (IMT) of the common carotid artery (CCA) was measured by an image-analysis system. The endothelium of the CCA was observed by scanning electron microscopy. The eNOS protein of the major artery was assayed by immunohistochemistry and western blotting. Results: Compared with the control group, PZ51 decreased plasma MDA (7.88±1.06 vs 10.88±1.73 nmol/l, p
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