Author: AGABITI-ROSEI ENRICO ZULLI ROBERTO MUIESAN MARIA LORENZA SALVETTI MASSIMO RIZZONI DAMIANO CORBELLINI CLAUDIA MONTEDURO CRISTINA
Publisher: Informa Healthcare
ISSN: 0803-7051
Source: Blood Pressure, Vol.7, Iss.3, 1998-08, pp. : 160-169
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Abstract
The aim of this study was to evaluate the effect of the calcium antagonist Nifedipine GITS in a double-blind, randomized comparison with the diuretic hydrochlorothiazide (HCTZ) on reduction of left ventricular (LV) mass and minimal vascular resistance in a group of essential hypertensives with left ventricular hypertrophy (LVH). The effects on blood pressure and on echocardiographic LV functional parameters were also analysed. After two months of randomized treatment with Nifedipine GITS or HCTZ, if diastolic blood pressure was > 90 mmHg, a combination of the two drugs was given and was continued for 24 weeks. M-mode, 2D-guided echocardiography was used to measure LV mass index (LVMI) according to the “Penn convention”. Minimal vascular resistance was measured in the forearm, from arterial pressure and maximal blood flow, using a strain gauge plethysmography. All examinations were performed before and after 8 and 24 weeks of treatment. Changes in LVMI were analysed at 8 weeks and at 24 weeks in patients receiving monotherapy (“according to protocol” analysis), and also at the end of treatment in patients taking Nifedipine or HCTZ monotherapy or the combination of the two drugs (“intention to treat” analysis). Both Nifedipine and HCTZ significantly reduced systolic and diastolic blood pressure (
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