Author: Shalom Rima Rimbroth Sofia Rozenman Dganit Markel Arie
Publisher: Informa Healthcare
ISSN: 0886-022X
Source: Renal Failure, Vol.30, Iss.3, 2008-03, pp. : 327-329
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Hyperuricemia is present in approximately 5% of the population. The vast majority is asymptomatic and at no clinical risk. Allopurinol, an analog of hypoxanthine, has been widely used in clinical practice for more than 30 years for the treatment of hyperuricemia and gout. Two percent of patients develop a mild exanthema when on this drug, which usually resolves after withdrawal of the drug. A syndrome characterized by exfoliative dermatitis, hepatitis, interstitial nephritis, and eosinophilia, termed allopurinol hypersensitivity syndrome, has been described, and its etiology related to the accumulation of one of allopurinol's metabolites, oxypurinol, of which clearance is decreased in the setting of renal insufficiency and the use of thiazide diuretics. The term DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) Syndrome has been recently used to describe an entity presenting with similar features.
Related content
By Dahlin Lars B. Lekholm Carl Kardum Peter Holmberg Jan
Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, Vol. 36, Iss. 3, 2002-06 ,pp. :