Author： Remeijer Lies Osterhaus Albert Verjans Georges
Publisher： Informa Healthcare
ISSN： 0927-3948
Source： Ocular Immunology and Inflammation, Vol.12, Iss.4, 2004-12, pp. : 255-285
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Abstract
Infections with several members of the human herpesviruses are the cause of significant ocular morbidity. Of the human herpesviruses, HSV-1 is the most frequent cause of primary and recurrent eye disease. Despite the availability of effective antiviral treatment, recurrent HSV-1 infection continues to be the leading cause of corneal blindness in industrialized nations. This review recapitulates the current insights in the role of the virus and the intra-corneal T cell response involved in the pathogenesis of human HSV-1-induced keratitis.
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