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Author: Moon Jeonggeun Rim Se-Joong Cho In Jeong Lee Sang-Hak Choi Seonghoon Chung Wook-Jin Byun Young-Sup Ryu Sung-Kee Pyun Wook-Bum Kim Jong-Youn
Publisher: Informa Healthcare
ISSN: 1064-1963
Source: Clinical and Experimental Hypertension, Vol.32, Iss.8, 2011-12, pp. : 540-546
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Regression of left ventricular (LV) hypertrophy (LVH) is known to be related to a lower incidence of stroke in hypertensive patients with nonvalvular atrial fibrillation (NV-AF). However, its mechanism remains controversial. Recently, diastolic dysfunction (DD) was reported to be correlated with ischemic stroke in NV-AF. We hypothesized that hypertension (HTN) and resultant LVH might be associated with the severity of DD in NV-AF. Two hundred and ninety-four patients (204 males, age 66 ±±± 12 y) with NV-AF with preserved LV systolic function were included. Clinical and echocardiographic data were compared between patients with enlarged left atrial (LA) volume (n === 237) and patients with normal LA. Age (60 ±±± 12 vs. 67 ±±± 11 years), sex (male; 81 vs. 62%%%), duration of NV-AF (4.1 ±±± 7.8 vs. 45.7 ±±± 49.0 months), brain natriuretic peptide (108.3 ±±± 129.3 vs. 236.1 ±±± 197.0 pg///mL), right ventricular systolic pressure (24.5 ±±± 5.5 vs. 33.1 ±±± 11.1 mmHg), mitral inflow velocity (E [77.4 ±±± 22.2 vs. 88.3 ±±± 22.0 cm///s]), LV mass index (LVMI [87.6 ±±± 22.2 vs. 105.1 ±±± 23.2 g///m2]), peak systolic mitral annular velocity (S' [7.2 ±±± 2.0 vs. 5.8 ±±± 1.8 cm///s]), and mitral inflow velocity to diastolic mitral annular velocity (E///E' [9.8 ±±± 3.4 vs. 12.1 ±±± 4.4]) were significantly different between the two groups, respectively (
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