Role of nitric oxide in cancer biology

Author: Moochhala Shabbir   Rajnakova Andrea  

Publisher: Informa Healthcare

ISSN: 1071-5762

Source: Free Radical Research, Vol.31, Iss.6, 1999-01, pp. : 671-679

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Abstract

The role of nitric oxide (NO) in tumorigenesis is multifactorial. NO can participate in the complicated process of carcinogenesis by mediating DNA damage in early phases of tumorigenesis, as well as support tumor progression through the induction of angiogenesis and suppression of the immune response. This paper addresses the effects of NO on transcriptional regulation following DNA damage and cyclooxygenase expression in the multistep process of tumorigenesis.