Author: Ohishi Kentaro Zhang Xiao Mei Moriwaki Shinichi Hiramitsu Tadahisa Matsugo Seiichi
Publisher: Informa Healthcare
ISSN: 1071-5762
Source: Free Radical Research, Vol.39, Iss.8, 2005-08, pp. : 875-882
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
We investigated the iron release from ferritin by irradiation from a white fluorescent light in the absence or presence of ADP. Irradiation of a ferritin solution at 17,000 lx in the absence of ADP slightly induces iron release from ferritin but only at acidic pH conditions (pH 5.0 or pH 6.0). Irradiation in the presence of ADP markedly enhances iron release from ferritin under the same conditions. In the absence of irradiation, the iron release from ferritin was low even in the presence of ADP. The induction of the iron release by irradiation in the presence of ADP was also affected by various factors such as irradiation dose and acidity, but not temperature (4–47°C), oxygen concentration, or free radical generations during the irradiation. The iron release during the irradiation ceased to increase by turning off the light and was found to increase again after additional irradiation. These results suggest that visible light directly induces iron release from ferritin via the photoreduction of iron stored inside ferritin.
Related content
Archives of Biochemistry and Biophysics, Vol. 346, Iss. 2, 1997-10 ,pp. :
By Ohishi Kentaro Zhang Xiao Mei Moriwaki Shinichi Hiramitsu Tadahisa Matsugo Seiichi
Free Radical Research, Vol. 40, Iss. 8, 2006-08 ,pp. :