Author: Haware Rahul V. Bauer-Brandl Annette Tho Ingunn
Publisher: Informa Healthcare
ISSN: 1083-7450
Source: Pharmaceutical Development and Technology, Vol.15, Iss.4, 2010-08, pp. : 394-404
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Abstract
The present work challenges a newly developed approach to tablet formulation development by using chemically identical materials (grades and brands of microcrystalline cellulose). Tablet properties with respect to process and formulation parameters (e.g. compression speed, added lubricant and Emcompress® fractions) were evaluated by 23-factorial designs. Tablets of constant true volume were prepared on a compaction simulator at constant pressure (approx. 100 MPa). The highly repeatable and accurate force-displacement data obtained was evaluated by simple ‘
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