(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors

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Publisher: Informa Healthcare

ISSN: 1354-3776

Source: Expert Opinion on Therapeutic Patents, Vol.7, Iss.10, 1997-10, pp. : 1211-1212

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Abstract

This patent describes synthesis and biological evaluation of a large number of cyclooxygenase-2 (COX-2) selective diarylfuranone inhibitors useful for the treatment of inflammatory diseases. A number of the specific analogues possess considerable anti-inflammatory activity in vivo.