Author： Lange C.S.
Publisher： Informa Healthcare
ISSN： 1362-3095
Source： International Journal of Radiation Biology, Vol.14, Iss.6, 1969-01, pp. : 539-551
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Abstract
The model of Lange and Gilbert (1968) which quantitatively relates the parameters of the planarian survival curve to those of the neoblast (planarian stem cell) survival curve also makes two non-trivial predictions. The first, that planarian mortality probability should decrease exponentially as the number of reproductively-intact neoblasts is increased (total tissue volume being kept constant), has already been verified. The second, that LD50 should decrease as a logarithmic function of the number of reproductively-intact neoblasts (total tissue volume being kept constant), is tested and confirmed. The RBE of 90Sr/90Y β-rays relative to 300 kVp x-rays was found to be 0·7 to 0·8 for D. lugubris. It is also shown that the planarian does not have a superfluity of stem cells, but only enough to ensure survival.Dose fractionation studies show that the neoblasts of D. etrusca can repair some sub-lethal damage within hours after irradiation and/or are triggered into cell cycle, some phases of which are relatively resistant as compared with the resting state.
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