The Effect of the Electron Affinic Sensitizers Ro 07-0582 and Ro 03-6156 on the Survival of Several E. Coli Mutants

Author: Fielden E. Martin   Sapora Orazio   Loverock Pamela S.  

Publisher: Informa Healthcare

ISSN: 1362-3095

Source: International Journal of Radiation Biology, Vol.33, Iss.1, 1978-01, pp. : 41-45

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Abstract

Concentration versus radiosensitizing effect curves have been determined for four E. Coli strains with two nitroaromatic sensitizers. The data are consistent with a simple competition kinetic model of sensitization, and K values for Ro 07-0582 are reported. An empirical relationship, DMF = α o.e.r., relating the dose-modifying factor produced by a given concentration of sensitizer to the oxygen-enhancement ratio of a bacterium was found to hold for all the mutants tested for values of α > 1/o.e.r. The limiting value of α at high concentrations of sensitizer was 0·75. Some implications of this relationship and the limiting value of α are discussed.

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