Dose-rate Dependence of Lung Damage after Total Body Irradiation in Mice

ISSN： 1362-3095

Source： International Journal of Radiation Biology, Vol.41, Iss.3, 1982-06, pp. : 325-334

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Idiopathic pneumonitis is a major cause of morbidity and mortality in patients with leukaemia undergoing total body irradiation (TBI) and bone marrow transplantation (BMT). The effect of variation in dose rate of TBI on the development of lethal and sublethal lung damage has been investigated in mice by measuring changes in carbon monoxide uptake. CBA mice were irradiated using a ⁶⁰Co source at 0·02, 0·05, 0·1, 0·2, 0·5 and 1·0 Gy min⁻¹ to a total dose of 15·5 Gy. A log-linear relationship between the severity of impairment of carbon monoxide uptake (.V_CO) and dose rate was found. Ventilatory requirement (ventilation rate/.V_CO) was raised 20 to 40 weeks after TBI at dose rates above 0·1 Gy min⁻¹. Time of onset and extent of elevation of ventilatory requirement were also dose-rate dependent. The implications of these findings for clinical practice are discussed.

Related content

Dose-dependence of the Time of Appearance of Lung Damage in Mice Given Thoracic Irradiation

By Collis C.H. Steel G.G.

International Journal of Radiation Biology, Vol. 42, Iss. 3, 1982-09 ,pp. : 245-252 (8)

Informa Healthcare

Access to resources Recommend Favorite

Compromising Effect of Low Dose-rate Total Body Irradiation on Allogeneic Bone Marrow Engraftment

By van Os R. Konings A.W.T. Down J.D.

International Journal of Radiation Biology, Vol. 64, Iss. 6, 1993-12 ,pp. : 761-770 (10)

Informa Healthcare

Access to resources Recommend Favorite

Calculation of the Dose-rate Dependence of the Dicentric Yield after Co γ-irradiation of Human Lymphocytes

By Bauchinger M. Schmid E. Dresp J.

International Journal of Radiation Biology, Vol. 35, Iss. 3, 1979-03 ,pp. : 229-233 (5)

Informa Healthcare

Access to resources Recommend Favorite

Abnormal Radiosensitivity of Lymphocytes from Breast Cancer Patients with Excessive Normal Tissue Damage after Radiotherapy: Chromosome Aberrations after Low Dose-rate Irradiation

By Jones L.A. Scott D. Cowan R. Roberts S.A.

International Journal of Radiation Biology, Vol. 67, Iss. 5, 1995-05 ,pp. : 519-528 (10)

Informa Healthcare

Access to resources Recommend Favorite

The Modification of Acute Mortality in Mice by Variation of the Dose-rate and the Overall Time of Irradiation

By Corp M.J. Neal F.E.

International Journal of Radiation Biology, Vol. 1, Iss. 3, 1959-07 ,pp. : 256-265 (10)

Informa Healthcare

Access to resources Recommend Favorite