Author： Nishimoto S. Ide H. Wada T. Kagiya T.
Publisher： Informa Healthcare
ISSN： 1362-3095
Source： International Journal of Radiation Biology, Vol.44, Iss.6, 1983-12, pp. : 585-600
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The effect of 20 electron-affinic compounds including nitroimidazoles, nitrofurans, nitrobenzenes, and quinones on the radiation-induced reaction of thymine in aqueous solution was studied under deaerated and N2O-saturated conditions. The radiolysis of thymine in aerated aqueous solution was also performed for comparison. Thymine decomposition was depressed to some extent by the addition of electron-affinic compounds in both deaerated and N2O-saturated solutions, while promoted in aerated solution. The radiolyses with varying concentration of misonidazole indicated that the depression of thymine decomposition can be attributed to a competition between thymine and electron-affinic compounds for the reactions with ·OH. Among the radiolysis products, the formation of thymine glycol was remarkably promoted by the addition of electron-affinic compounds. Irrespective of structures of the electron-affinic compounds, the
Related content
Electron-affinic Sensitization
International Journal of Radiation Biology, Vol. 15, Iss. 5, 1969-07 ,pp. :
Access to resources
Recommend
Radiation-induced Thymine Formation from Thymine Glycol
International Journal of Radiation Biology, Vol. 17, Iss. 2, 1970-03 ,pp. :