Serum interferon-gamma (IFN-&ggr;) in chronic oral candidosis

Author: Szkaradkiewicz A.   Szponar E.   Krzeminska-Jaskowiak E.   Tuecka T.  

Publisher: Informa Healthcare

ISSN: 1460-2709

Source: Medical Mycology, Vol.36, Iss.5, 1998-10, pp. : 269-273

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Abstract

Serum IFN-&ggr; levels were studied in adult patients with chronic oral candidosis, associated with Candida albicans infection. In the group of patients, mean serum IFN-&ggr; levels (2·74±4·65 pg ml-1) were significantly lower than in healthy individuals (9·80±1·68 pg ml-1). In analysis of the C. albicans strains isolated from lesions in the patients, their ability was estimated to secrete proteinases. Serum IFN-&ggr; levels failed to correlate with infections induced by proteinase-producing C. albicans. The results allowed us to conclude that Candida infection may be associated with an insufficient IFN-&ggr; response of the host, which seems to result in chronic conversion of candidosis. Proteolytic activity of C. albicans strains in vitro is not related to virulence of the strains.