Author： Lawrie Charles H
Publisher： Informa Healthcare
ISSN： 1471-2598
Source： Expert Opinion on Biological Therapy, Vol.7, Iss.9, 2007-09, pp. : 1363-1374
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Abstract
MicroRNAs are a recently discovered class of short (∼ 22 nucleotide) naturally occurring RNA molecules that negatively regulate gene expression post-transcriptionally. There has been an explosion of interest in the microRNA field as these molecules have been found to play key roles in a wide range of biological processes and to be aberrantly expressed in many types of cancer, including haematological malignancies. Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g.,
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