Tumour-immune cell interactions modulated by chemokines

Author： Jhrer Karin   Pleyer Lisa   Olivier Angelika   Maizner Eva   Zelle-Rieser Claudia   Greil Richard  

Publisher： Informa Healthcare

ISSN： 1471-2598

Source： Expert Opinion on Biological Therapy, Vol.8, Iss.3, 2008-03, pp. : 269-290

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

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Abstract

Background: Chemokines are involved in almost all aspects of tumour establishment and progression. Objective: This review gives an insight into the complexity of chemokines and chemokine signalling in tumours, especially focusing on the tuning of the immune system within the tumour microenvironment. Methods: Experimental evidence from manipulation of the chemokine network in murine models and in vitro data are critically discussed, and the current status and potential future interventions therapeutically targeting chemokines for efficient and long-lasting tumour control in cancer patients are described.

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