Transition Metal Acetylsalicylates and Their Anti-inflammatory Activity

Author: Chohan Zahid H.   Iqbal Hummara Sadia   Scozzafava Andrea   Supuran Claudiu T.   Iqbal Mohammad S.  

Publisher: Informa Healthcare

ISSN: 1475-6366

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol.17, Iss.2, 2002-01, pp. : 87-91

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Abstract

Mononuclear and binuclear transition metal [Co(II), Cu(II), Ni(II) and Zn(II)] acetylsalicylates of the type [M(L)2], [M(L)2Cl2] and [(M)2(L)4] have been prepared and characterized on the basis of their physical, spectral and analytical data. The complexes have been investigated in an in vivo animal model for anti-inflammatory activity and show a better effect and a more potent action than acetylsalicylic acid.

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