Author： Chohan Zahid H. Pervez Humayun Rauf Abdul Khan Khalid M. Supuran Claudiu T.
Publisher： Informa Healthcare
ISSN： 1475-6366
Source： Journal of Enzyme Inhibition and Medicinal Chemistry, Vol.21, Iss.2, 2006-04, pp. : 193-201
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Abstract
A series of Co (II), Cu (II), Ni (II) and Zn (II) complexes of mercaptothiadiazole—derived furanyl, thienyl, pyrrorlyl, salicylyl and pyridinyl Schiff bases were synthesized, characterized and screened for their in vitro antibacterial activity against four Gram-negative, Escherichia coli , Pseudomonas aeruginosa , Salmonella typhi and Shigella flexneri, and two Gram-positive; Bacillus subtilis and Staphylococcus aureous bacterial strains. The results of these studies show the metal complexes to be more antibacterial as compared to the prepared un-complexed Schiff bases.
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