Author: Jiao Jie Fang Hao Wang Xuejian Zhu Huawei Jiang Lan Xu Wenfang
Publisher: Informa Healthcare
ISSN: 1475-6366
Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol.25, Iss.1, 2010-01, pp. : 132-138
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Abstract
Histone deacetylases (HDACs) play an important role in gene transcription, cellular proliferation, apoptosis, and tumorigenesis. A novel series of benzylether-containing cinnamoyl derivatives were designed and synthesized as inhibitors of histone deacetylases (HDACs). Most of these compounds possessed inhibitory activity against the enzymes with IC50 values as low as 30 μM. In addition, compounds
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