The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy

Author： Brar Herb   Wang Eric   Struble Craig   Musci Thomas J.   Norton Mary E.  

Publisher： Informa Healthcare

ISSN： 1476-4954

Source： Journal of Maternal-Fetal and Neonatal Medicine, Vol.26, Iss.2, 2013-01, pp. : 143-145

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Abstract

Objective: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. Methods: A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal screening results, or nuchal translucency measurement. Results: Across the highest and lowest deciles within each group, there were no significant differences in the fetal cfDNA fraction. Conclusions: These data support the concept that non-invasive prenatal test performance as determined by fetal cfDNA fraction is not predicted to be different based on patient risk classification.

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