Author： Tiwari Amit Kumar Gajbhiye Virendra Sharma Rajeev Jain Narendra Kumar
Publisher： Informa Healthcare
ISSN： 1521-0464
Source： Drug Delivery, Vol.17, Iss.8, 2010-11, pp. : 605-616
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Abstract
Proteins and peptides are complex macromolecules that are prone to change in their native structure during storage, which causes undesired side-effects after their administration. During past decades, bioactive carriers have played an important role in stabilization of proteins. Incorporation of the protein and peptides into a particulate carrier can protect it against degradation in vitro and in vivo, the release can be controlled, and it also offers possibilities for targeting. This review has focused on a wide range of bioactive carriers used in protein stabilization during long time storage. Bioactive carriers can protect the bioactives from degradation, resulting in increased bioavailability of protein.
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