Author： Yaralı Neşe Fışgın Tunç Duru Feride Atilla Pergin Müftüoğlu Sevda Kaymaz S.
Publisher： Informa Healthcare
ISSN： 1521-0669
Source： Pediatric Hematology and Oncology, Vol.22, Iss.4, 2005-06, pp. : 265-270
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Congenital dyserythropoietic anemia type I (CDA I) is a rare inherited hematological disorder characterized by macrocytic anemia and ineffective erythropoiesis with pathognomonic morphological features that include internuclear chromatin bridges, spongy heterochromatin, and invagination of the cytoplasm into the nuclear area in erythroid precursors. Treatment of anemia with the usual hematinics is without effect and 15% of patients need chronic transfusions. Successful treatment of CDA I with interferon-a was noted. The authors report a patient with CDA I who had required transfusions every 2–3 months since the neonatal period and responded to recombinant interferon-a therapy with the findings of electron microscopic investigations.
Related content
By Tamary Hannah Tiqva Petah Shalev Hanna Pinsk Vered Sheva Beer Zoldan Meira Zaizov Rina Tiqva Petah
Pediatric Hematology and Oncology, Vol. 16, Iss. 2, 1999-03 ,pp. :
Access to resources
Recommend
By Tekinalp Gülsevin Sarící S. Ümit Erdinç A. Seval Gögüş Safiye Balcí Sevim Gürgey Aytemiz
Pediatric Hematology and Oncology, Vol. 18, Iss. 8, 2001-12 ,pp. :
By Anoop Parameswaran Lancaster Donna L. Rassam Saad M. B. Atra Ayad
Pediatric Hematology and Oncology, Vol. 29, Iss. 2, 2012-02 ,pp. :