Author: Capitini Christian M. Gottschalk Stephen Brenner Malcolm Cooper Laurence J. N. Handgretinger Rupert Mackall Crystal L.
Publisher: Informa Healthcare
ISSN: 1521-0669
Source: Pediatric Hematology and Oncology, Vol.28, Iss.6, 2011-08, pp. : 459-460
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The Second International Conference on Immunotherapy in Pediatric Oncology was held in Houston, Texas, USA, October 11–12, 2010, to discuss the progress and challenges that have occurred in cutting edge immunotherapeutic strategies currently being developed for pediatric oncology. Major topics included immune targeting of acute lymphoblastic leukemia and pediatric solid tumors, chimeric antigen receptors (CARs) for hematologic malignancies and solid tumors, enhancing graft-versus-leukemia for pediatric cancers, overcoming hurdles of immunotherapy, strategies to active the innate immune system, and moving immunotherapy beyond phase I studies. Significant progress has been made in the last 2 years both in the development of novel immunobiologics such as CARs, and in establishing survival benefits of an anti-GD2 monoclonal antibody in randomized studies. Although there is much excitement going forward, a great deal of laboratory and regulatory challenges lie ahead in improving the efficacy of each of these modalities as well as getting them to patients in a timely and cost-effective fashion. The resulting discussions will hopefully lead to new collaborations and insight for further translational and clinical studies.
Related content
PEDIATRIC HEMATOLOGY AND ONCOLOGY IN IRAN
Pediatric Hematology and Oncology, Vol. 22, Iss. 1, 2005-01 ,pp. :
PEDIATRIC ONCOLOGY AND THE INTERNET
Pediatric Hematology and Oncology, Vol. 18, Iss. 6, 2001-08 ,pp. :
Current Pediatric Reviews, Vol. 2, Iss. 4, 2006-11 ,pp. :
PET imaging in pediatric oncology
Pediatric Radiology, Vol. 34, Iss. 3, 2004-03 ,pp. :