Biodegradable gentamicin delivery systems for parenteral use for the treatment of intracellular bacterial infections

Author： Gamazo Carlos Prior Sandra Concepción Lecároz María Vitas Ana Isabel Campanero Miguel Angel Pérez Guiomar Gonzalez David Blanco-Prieto María Jose

Publisher： Informa Healthcare

ISSN： 1742-5247

Source： Expert Opinion on Drug Delivery, Vol.4, Iss.6, 2007-11, pp. : 677-688

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Abstract

Gentamicin is an aminoglycoside with a wide spectrum of antibacterial activity. However, as a highly water-soluble drug, it penetrates cells poorly. This constitutes a particularly important drawback for treating intracellular bacterial infections. This major hurdle may be solved by the use of vectors to deliver and target bioactive agents to the intracellular sites of infection. Thus, in the case of antimicrobials, drug delivery systems may help to increase their therapeutic index in intracellular locations. The development and evolution of pharmaceutical forms of gentamicin for the parenteral treatment of intracellular pathogens is reviewed in this paper.