Allergens and Respiratory Pollutants ：The Role of Innate Immunity ( Woodhead Publishing Series in Biomedicine )

Publication subTitle ：The Role of Innate Immunity

Publication series ：Woodhead Publishing Series in Biomedicine

Author： Williams Marc A.

Publisher： Elsevier Science‎

Publication year： 2011

E-ISBN: 9781908818065

P-ISBN(Paperback): 9781907568541

P-ISBN(Hardback): 9781907568541

Subject： R392 medical immunology;R5 Internal Medicine

Language： ENG

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Description

Allergens and respiratory pollutants is a collection of 12 authoritative papers that draws upon the collective expertise of world leaders in the fields of innate immunity, immunotoxicology and pulmonary biology. The book critically explores the biological and immunological mechanisms that contribute to immune dysfunction on exposure to allergens and the susceptibility to infectious disease on exposure to ambient pollutants. The clinical relevance of exposure to ambient airborne xenobiotics is critically discussed and collectively, this book provides an educational forum that links the health effects of environmental exposures, immune dysfunction and inflammatory airways disease.

Discusses recent advances in our understanding of cell-mediated innate immune mechanisms that occur during allergic inflammation and provides important timely coverage of diseases of concern and how such diseases are influenced by a dysfunctional immune system
Provides useful information on linking environmental 'danger signals' that provoke immune dysfunction and exacerbation of existing disease
Draws upon the collective expertise of an international college of leaders in the field, but also provides chapters that provide essential reference material

Chapter

Cover

pp.： 1 – 3

Wood head Publishing Seriesin Biomedicine

pp.： 3 – 8

Allergens and respiratory pollutants: The role of innate immunity

pp.： 8 – 9

pp.： 9 – 10

Contents

pp.： 10 – 16

List of illustrations

pp.： 16 – 18

Editor’s note

pp.： 18 – 20

About the editor and contributors

pp.： 20 – 30

1 An introduction to allergic inflammation and the innate immune sensing of dangerous ambient pollutants by the dendritic cell

pp.： 30 – 66

2 Asthma: primary immunomodulatory pathways

pp.： 66 – 80

3 Environmental lung injury and pattern recognition receptors

pp.： 80 – 118

4 Asthma exacerbations: a paradigm of synergy between allergens, pollutants and viruses

pp.： 118 – 146

5 Bronchial hyperresponsiveness and lung inflammation induced by allergic immune response and oxidative stress: role of innate and adaptive immune responses

pp.： 146 – 168

6 Effects of air pollutants on allergic sensitization through the airway

pp.： 168 – 186

7 Particulate matter and oxidative stress: dangerous partners in inflammation, vascular dysfunction and innate immunity

pp.： 186 – 200

8 Diesel exhaust particles and the airway epithelial cell–dendritic cell interface in the control of immune homeostasis

pp.： 200 – 230

9 Role of macrophages in adverse pulmonary effects of particulate pollutants

pp.： 230 – 242

10 Particulate air pollution and vulnerability to respiratory infections in children

pp.： 242 – 258

11 The intersection of respiratory syncytial virus infection, innate immunity and allergic lung disease

pp.： 258 – 274

12 Interactions between allergens and dendritic cells: pattern recognition receptors and their function in the pathogenesis of allergic respiratory diseases

pp.： 274 – 306

Index

pp.： 306 – 316

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