Prion Diseases and Copper Metabolism ：Bse, Scrapie and CJD Research

Publication subTitle ：Bse, Scrapie and CJD Research

Author： Brown D.

Publisher： Elsevier Science‎

Publication year： 2002

E-ISBN: 9780857099914

P-ISBN(Paperback): 9781898563877

P-ISBN(Hardback): 9781898563877

Subject： TS2 food industry

Language： ENG

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Description

International authorities here investigate research into the prion diseases which include Scrapie of sheep, BSE the "Mad Cow" disease, and CJD one of the human diseases. The role of metals in these diseases has become of great importance, linking it with some of the changes in Alzheimer's disease. The book focuses on metabolism of copper and manganese which are found in these diseases. It stems from proceedings of the international workshop at Christ's College, Cambridge University in 2001. After an introduction on the history of research into the diseases, there are discussions on the effects of copper on biochemical properties and prion proteins of brain cells, and newer techniques for their study. There is also a section on the relationship of Alzheimers disease to prion diseases.

Focuses on metabolism of copper and manganese, which are found in Scrapie of sheep; BSE, the "Mad Cow" disease; and CJD, one of the human prion diseases
Discusses the effects of copper on biochemical properties, prion proteins of brain cells and new techniques for their study
Stems from the proceedings of the international workshop at Christ’s College, Cambridge University in 2001

Chapter

Front Cover

pp.： 1 – 4

Dedication

pp.： 2 – 6

Prion Diseases and Copper Metabolism: BSE, Scrapie and CJD Research

pp.： 4 – 5

pp.： 5 – 8

Address of Corresponding or Main Authors

pp.： 6 – 10

Table of Contents

pp.： 8 – 2

Chapter 1. Introduction

pp.： 10 – 16

Chapter 2. Copper – Prion Protein, Molecular Interactions

pp.： 16 – 34

Chapter 3. The Effects of Copper on the Cellular Trafficing and Biochemical Properties of the Prion Protein

pp.： 34 – 45

Chapter 4. Tracing the Copper Binding to the Murine Prion Protein using Electron Paramagnetic Resonance

pp.： 45 – 67

Chapter 5. Co-ordinate Binding of Copper to Prion Protein

pp.： 67 – 76

Chapter 6. Oxidative Stress, Metal Ions and Neurodegenerative Diseases

pp.： 76 – 88

Chapter 7. Near Infrared Spectroscopy for Nondestructive Study of Prion Protein Isoforms

pp.： 88 – 105

Chapter 8. Prion and Alzheimer Diseases: The Road to Pathogenesis is Paved with Copper

pp.： 105 – 111

Chapter 9. The Copper Binding Domain of the Amyloid Precursor Protein of Alzheimer's Disease can Modulate Copper Homeostasis and Regulate Amyloid Aß Production

pp.： 111 – 117

Chapter 10. Metals modulate the aggregation and neurotoxic properties of the prion peptide PrP106-126

pp.： 117 – 128

Chapter 11. Human CJD and Trace Elements

pp.： 128 – 142

Chapter 12. Metals and Human Prion Disease

pp.： 142 – 146

Chapter 13. Disease Progression and Metal Aberrations

pp.： 146 – 165

Chapter 14. Environmental Fate of the Trace Elements Copper and Manganese in Soils

pp.： 165 – 196

Chapter 15. Conclusion: Future Directions for Copper and the Prion Protein

pp.： 196 – 204

Chapter 16. REFERENCES

pp.： 204 – 266

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