Fundamentals of Advanced Omics Technologies: From Genes to Metabolites ( Volume 63 )

Publication series :Volume 63

Author: Simó   Carolina;Cifuentes   Alejandro;García-Cañas   Virginia  

Publisher: Elsevier Science‎

Publication year: 2014

E-ISBN: 9780444626707

P-ISBN(Paperback): 9780444626516

P-ISBN(Hardback):  9780444626516

Subject: O6 Chemistry;O65 Analytical Chemistry

Language: ENG

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Description

Fundamentals of Advanced Omics Technologies: From Genes to Metabolites covers the fundamental aspects of the new instrumental and methodological developments in omics technologies, including those related to genomics, transcriptomics, epigenetics, proteomics and metabolomics, as well as other omics approaches such as glycomics, peptidomics and foodomics. The principal applications are presented in the following complementary volume.

The chapters discuss in detail omics technologies, DNA microarray analysis, next-generation sequencing technologies, genome-wide analysis of methylation and histone modifications, emerging nanotechniques in proteomics, imaging mass spectrometry in proteomics, recent quantitative proteomics approaches, and advances in high-resolution NMR-based metabolomics, as well as MS-based non-targeted metabolomics and metabolome analysis by CE-MS, global glycomics analyses, foodomics, and high resolution analytical tools for quantitative peptidomics. Key aspects related to chemometrics, bioinformatics, data treatment, data integration and systems biology, deep-sequencing data analysis, statistical approaches for the analysis of microarray data, the integration of transcriptome and metabolome data and computational approaches for visualization and integration of omics data are also covered.

  • Covers the latest advances in instrumentation, experimental design, sample preparation, and data analysis
  • Provides thorough explanations

Chapter

Front Cover

pp.:  1 – 4

Copyright

pp.:  5 – 6

Contents

pp.:  6 – 14

Contributors to Volume 63

pp.:  14 – 18

Series Editor´s Preface

pp.:  18 – 20

Preface

pp.:  20 – 22

Chapter 2: Challenges and Future Trends in DNA Microarray Analysis

pp.:  46 – 68

Chapter 3: Next-Generation Sequencing: New Tools to Solve Old Challenges

pp.:  68 – 102

Chapter 4: Omics Tools for the Genome-Wide Analysis of Methylation and Histone Modifications

pp.:  102 – 132

Chapter 5: An Overview of Quantitative Proteomic Approaches

pp.:  132 – 158

Chapter 6: Emerging Nanotechniques in Proteomics

pp.:  158 – 180

Chapter 7: Mass Spectrometry Imaging in Proteomics and Metabolomics

pp.:  180 – 208

Chapter 8: Advances in NMR-Based Metabolomics

pp.:  208 – 234

Chapter 9: The Role of Mass Spectrometry in Nontargeted Metabolomics

pp.:  234 – 256

Chapter 10: Direct Mass Spectrometry-Based Approaches in Metabolomics

pp.:  256 – 276

Chapter 11: Functional Glycomics Analysis

pp.:  276 – 302

Chapter 12: Applications of Glycan Microarrays to Functional Glycomics

pp.:  302 – 326

Chapter 13: High-Resolution Analytical Tools for Quantitative Peptidomics

pp.:  326 – 346

Chapter 14: Analysis of Deep Sequencing Data: Insights and Challenges

pp.:  346 – 376

Chapter 15: Gene Expression Analysis and Profiling of Microarrays Data and RNA-Sequencing Data

pp.:  376 – 406

Chapter 16: Bioinformatic Approaches to Increase Proteome Coverage

pp.:  406 – 442

Chapter 17: Transcriptome and Metabolome Data Integration-Technical Perquisites for Successful Data Fusion and Visualization

pp.:  442 – 464

Chapter 18: Computational Approaches for Visualization and Integration of Omics Data

pp.:  464 – 476

Index

pp.:  476 – 489

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