Recent Advances in Parkinsons Disease :Part II: Translational and Clinical Research ( Volume 184 )

Publication subTitle :Part II: Translational and Clinical Research

Publication series :Volume 184

Author: Bjorklund   Anders;Cenci-Nilsson   Angela  

Publisher: Elsevier Science‎

Publication year: 2010

E-ISBN: 9780444537515

P-ISBN(Paperback): 9780444537508

P-ISBN(Hardback):  9780444537508

Subject: Q189 Neurobiology;R741 Neurology

Language: ENG

Access to resources Favorite

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Description

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.

  • Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications
  • Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Chapter

Cover

pp.:  1 – 2

Copyright

pp.:  5 – 6

List of Contributors

pp.:  6 – 8

Preface

pp.:  8 – 10

Contents

pp.:  10 – 12

Section I. Animal models of PD

pp.:  12 – 14

Chapter 2. Neurotoxic in vivo models of Parkinson’s disease: recent advances

pp.:  28 – 46

Chapter 3. Behavioral analysis of motor and non-motor symptoms in rodent models of Parkinson’s disease

pp.:  46 – 64

Chapter 4. Genetic mouse models of Parkinson’s disease: The state of the art

pp.:  64 – 100

Chapter 5. Viral vector-mediated overexpression of a-synuclein as a progressive model ofParkinson’s disease

pp.:  100 – 124

Chapter 6. Modeling neuroinflammatory pathogenesis of Parkinson’s disease

pp.:  124 – 144

Chapter 7. The MPTP-lesioned non-human primate models of Parkinson’s disease. Past,present, and future

pp.:  144 – 170

Section II. Exploring PD with brain imaging

pp.:  170 – 172

Chapter 8. Abnormal metabolic brain networks in Parkinson’s disease: from blackboard to bedside

pp.:  172 – 188

Chapter 9. Imaging the nigrostriatal system to monitor disease progression andtreatment-induced complications

pp.:  188 – 204

Chapter 10. Brain imaging after neural transplantation

pp.:  204 – 216

Chapter 11. Imaging non-motor aspects of Parkinson’s disease

pp.:  216 – 230

Section III. Frontiers in PD treatment

pp.:  230 – 232

Chapter 12. Gene therapy for dopamine replacement

pp.:  232 – 248

Chapter 13. Neurotrophic factor therapy for Parkinson’s disease

pp.:  248 – 276

Chapter 14. Neural grafting in Parkinson’s disease: problems and possibilities

pp.:  276 – 306

Chapter 15. Neural grafting in Parkinson’s disease: unraveling the mechanisms underlyinggraft-induced dyskinesia

pp.:  306 – 322

Chapter 16. Deep brain stimulation: state of the art and novel stimulation targets

pp.:  322 – 336

Chapter 17. The challenge of non-motor symptoms in Parkinson’s disease

pp.:  336 – 354

Subject Index

pp.:  354 – 370

The users who browse this book also browse