Mutagenic Effects of Environmental Contaminants

Author: Sutton   H. E.  

Publisher: Elsevier Science‎

Publication year: 2012

E-ISBN: 9780323160100

P-ISBN(Paperback): 9780126779509

P-ISBN(Hardback):  9780126779509

Subject: X503 hazards of environmental pollution

Language: ENG

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Description

Mutagenic Effects of Environmental Contaminants investigates the mutagenic consequences of environmental contaminants, such as pesticides, industrials, food additives, drugs, and biologicals, as well as the possible relationships between mutagenesis and carcinogenesis. It describes the monitoring of chemical mutagens in the environment and the ways that genetic mutations cause disease in humans.

Organized into 14 chapters, this volume begins with an overview of the current burden of human genetic disease and the biochemical mechanisms of mutation. It then discusses practical and feasible methods that use a variety of organisms to screen potential mutagenic agents, increased mutation rates in human populations, mutagens that are currently used commercially, and the interrelationships between mutagenicity, carcinogenicity, and teratogenicity. The reader is also introduced to genetic toxicology, detection of chemically induced mutations in experimental animals, and chromosome and somatic mutations in humans.

This book is a valuable resource for scientists, policymakers, and administrators of environmental programs.

Chapter

Front Cover

pp.:  1 – 4

Copyright Page

pp.:  5 – 6

Table of Contents

pp.:  6 – 10

ORGANIZING PANEL

pp.:  10 – 12

CONTRIBUTORS

pp.:  12 – 14

PREFACE

pp.:  14 – 18

CHAPTER 1. INTRODUCTION: GENETIC TOXICOLOGY

pp.:  18 – 20

CHAPTER 2. GENE MUTATION AS A CAUSE OF HUMAN DISEASE

pp.:  20 – 32

CHAPTER 3. THE MOLECULAR BASIS OF MUTATION

pp.:  32 – 44

CHAPTER 4. MONITORING OF CHEMICAL MUTAGENS IN OUR ENVIRONMENT

pp.:  44 – 58

CHAPTER 5. THE DETECTION OF MUTATIONS WITH NON-MAMMALIAN SYSTEMS

pp.:  58 – 74

CHAPTER 6. A BACTERIAL SYSTEM FOR DETECTING MUTAGENS AND CARCINOGENS

pp.:  74 – 84

CHAPTER 7. THE NEED TO DETECT CHEMICALLY INDUCED MUTATIONS IN EXPERIMENTAL ANIMALS

pp.:  84 – 98

CHAPTER 8. CHROMOSOME MUTATIONS IN MAN

pp.:  98 – 116

CHAPTER 9. THE DETECTION OF INCREASED MUTATION RATES IN HUMAN POPULATIONS

pp.:  116 – 138

CHAPTER 10. MONITORING SOMATIC MUTATIONS IN HUMAN POPULATIONS

pp.:  138 – 146

CHAPTER 11. PESTICIDAL, INDUSTRIAL, FOOD ADDITIVE, AND DRUG MUTAGENS

pp.:  146 – 188

CHAPTER 12. MUTAGENICITY OF BIOLOGICALS

pp.:  188 – 194

CHAPTER 13. POSSIBLE RELATIONSHIPS BETWEEN MUTAGENESIS AND CARCINOGENESIS

pp.:  194 – 202

CHAPTER 14. INTERRELATIONS BETWEEN CARCINOGENICITY, MUTAGENICITY, AND TERATOGENICITY

pp.:  202 – 213