Monoclonal Antibodies :Probes for The Study of Autoimmunity and Immunodeficiency

Publication subTitle :Probes for The Study of Autoimmunity and Immunodeficiency

Author: Haynes   Barton  

Publisher: Elsevier Science‎

Publication year: 2012

E-ISBN: 9780323155434

P-ISBN(Paperback): 9780123348807

P-ISBN(Hardback):  9780123348807

Subject: R457.2 serum therapy, immune therapy

Language: ENG

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Description

Monoclonal Antibodies: Probes for the Study of Autoimmunity and Immunodeficiency focuses on the research/studies using monoclonal antibodies in two major classes of diseases, which are autoimmunity and immunodeficiency. The book comprises of 14 chapters; each is written in detail and includes studies using monoclonal antibodies of the pathogenesis and treatment of various types of diseases of disordered immunity.
The first chapter presents an overview of the use of monoclonal antibodies in the study of autoimmunity and immunodeficiency. The following chapters focus on other monoclonal reagents and their uses and applications to different diseases. The last four chapters discuss specific classic endocrine diseases in reference to discoveries regarding the beginning of autoimmune mechanisms and pathophysiology.
Because the book is technically written, students with background in biology, microbiology, and biochemistry are most likely the target audience of this book. Other parties in the fields of immunology, clinical medicine, pathology, and physiology will also find this book a good reference material.

Chapter

Front Cover

pp.:  1 – 4

Copyright Page

pp.:  5 – 6

Table of Contents

pp.:  6 – 12

Contributors

pp.:  12 – 16

Preface

pp.:  16 – 20

Chapter 1. Use of Monoclonal Antibodies in the Study of Autoimmunity and Immunodeficiency

pp.:  20 – 40

Chapter 2. Monoclonal Antilymphocyte Antibodies: Probes for the Study of the Regulation of Hematopoiesis and Potential Clinical Applications

pp.:  40 – 66

Chapter 3. Use of Monoclonal Antibodies to Identify Cell-Surface Antigens of Human Neuroendocrine Thymic Epithelium

pp.:  66 – 86

Chapter 4. Role of Prethymic and Intrathymic Elements in the Induction of T Cell Tolerance to Allogeneic Determinants: The Thymus Is Not Sufficient to Prevent Autoreactivity

pp.:  86 – 102

Chapter 5. Studies of Patients with Severe Cellular and Humoral Immunodeficiency Diseases Using Monoclonal Antibodies

pp.:  102 – 116

Chapter 6. The Use of Monoclonal Antibodies to Characterize Human Natural Killer Cell Ontogeny and Function

pp.:  116 – 134

Chapter 7. Utilization of Monoclonal Antibodies in the Study of Cell-Surface Antigens on Human B Lymphocytes

pp.:  134 – 150

Chapter 8. The Establishment of Human–Human and Human–Mouse B Cell Hybrids and Their Use in the Study of B Cell Activation

pp.:  150 – 172

Chapter 9. Murine Hybridomas Producing Autoantibodies from MRL Mice

pp.:  172 – 192

Chapter 10. Dual Recognition by Coupled Receptors in a Model of T Lymphocyte Differentiation

pp.:  192 – 216

Chapter 11. Type I Diabetes: Autoimmunity and Immunodeficiency

pp.:  216 – 240

Chapter 12. Autoimmune Thyroid Disease Studied with Monoclonal Antibodies to the Thyrotropin Receptor

pp.:  240 – 278

Chapter 13. Use of Monoclonal Antibodies in the Study of Myasthenia Gravis

pp.:  278 – 316

Chapter 14. Peripheral T Cell Circulatory Kinetics and Intrathymic T Cell Differentiation in Myasthenia Gravis

pp.:  316 – 334

Index

pp.:  334 – 338

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