Molecular Mechanisms Of Oxygen Activation

Author: Hayaishi   Osamu  

Publisher: Elsevier Science‎

Publication year: 2012

E-ISBN: 9780323143264

P-ISBN(Paperback): 9780123336408

P-ISBN(Hardback):  9780123336408

Subject: Q7 Molecular Biology

Language: ENG

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Description

Molecular Mechanisms of Oxygen Activation reviews some of the major advances that have been made in our understanding of the molecular mechanisms underlying oxygen activation, with emphasis on the role of oxygen activation in contemporary biological processes. The biological role of oxygenases in the metabolism of fatty acids and steroids is discussed, along with the functions of heme-containing dioxygenases, α-ketoglutarate-coupled dioxygenases, and pterin-requiring aromatic amino acid hydroxylases.
This book is comprised of 14 chapters and begins with an overview of the general properties and biological functions of oxygenases, along with the chemical aspects of oxygen fixation reactions. The reader is then introduced to research concerning fatty acid and steroid oxygenases which has appeared in the literature since 1962, paying particular attention to the mechanism of oxygenation and the biosynthesis and metabolism of steroids. Subsequent chapters explore the biological functions of a variety of oxygenases such as heme-containing dioxygenases, copper-containing oxygenases, flavoprotein oxygenases, and pterin-requiring aromatic amino acid hydroxylases. Superoxide dismutase, cytochrome c oxidase, peroxidase, and bacterial monoxygenases are also considered.
This monograph should serve as a valuable reference for biochemists as well as undergraduate and graduate students of biochemistry.

Chapter

Front Cover

pp.:  1 – 4

Copyright Page

pp.:  5 – 6

Table of Contents

pp.:  6 – 12

List of Contributors

pp.:  12 – 16

Preface

pp.:  16 – 18

Chapter 2. Oxygenases in Fatty Acid and Steroid Metabolism

pp.:  46 – 104

Chapter 3. Heme-Containing Dioxygenases

pp.:  104 – 152

Chapter 4. Nonheme Iron Dioxygenase

pp.:  152 – 184

Chapter 5. α-Ketoglutarate-Coupled Dioxygenases

pp.:  184 – 232

Chapter 6. Microsomal Cytochrome P-450-Linked Monooxygenase Systems in Mammalian Tissue

pp.:  232 – 262

Chapter 7. Flavoprotein Oxygenases

pp.:  262 – 302

Chapter 8. Pterin-Requiring Aromatic Amino Acid Hydroxylases

pp.:  302 – 388

Chapter 9. Copper-Containing Oxygenases

pp.:  388 – 422

Chapter 10. Chemical Models and Mechanisms for Oxygenases

pp.:  422 – 470

Chapter 11. Superoxide Dismutase

pp.:  470 – 496

Chapter 12. Cytochrome c Oxidase

pp.:  496 – 552

Chapter 13. Peroxidase

pp.:  552 – 576

Chapter 14. Bacterial Monoxygenases—The P450 Cytochrome System

pp.:  576 – 632

Author Index

pp.:  632 – 668

Subject Index

pp.:  668 – 698

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