Biothermodynamics, Part D ( Volume 492 )

Publication series ：Volume 492

Author： Johnson   Michael L.;Holt   Jo M.;Ackers   Gary K.  

Publisher： Elsevier Science‎

Publication year： 2011

E-ISBN: 9780123860040

P-ISBN(Paperback): 9780123860033

P-ISBN(Hardback):  9780123860033

Subject： Q5 Biochemistry;Q7 Molecular Biology

Language： ENG

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Description

The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.

* Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules * Provides a "must-have" methods volume that keeps MIE buyers and online subscribers up-to-date with the latest research * Offers step-by-step lab instructions, including necessary equipment, from a global research community

Chapter

Front Cover

pp.：  1 – 4

Biothermodynamics,Part D

pp.：  4 – 5

Copyright

pp.：  5 – 6

Contents

pp.：  6 – 10

Contributors

pp.：  10 – 14

Preface

pp.：  14 – 16

Methods in Enzymology

pp.：  16 – 46

Chapter 1: A Thermodynamic Approach for the Targeting of Nucleic Acid Structures Using Their Complementary Single Strands

pp.：  46 – 72

Chapter 2: Thermodynamics of Biological Processes

pp.：  72 – 106

Chapter 3: Protein Stability in the Presence of Cosolutes

pp.：  106 – 172

Chapter 4: Small-Angle X-ray Scattering Studies of Peptide-Lipid Interactions Using the Mouse Paneth Cell α-Defensin Cryptdin

pp.：  172 – 196

Chapter 5: Synergy of Molecular Dynamics and Isothermal Titration Calorimetry in Studies of Allostery

pp.：  196 – 234

Chapter 6: Using Tryptophan Fluorescence to Measure the Stability of Membrane Proteins Folded in Liposomes

pp.：  234 – 258

Chapter 7: Non-B Conformations of CAG Repeats Using 2-Aminopurine

pp.：  258 – 278

Chapter 8: Disulfide Bond-Mediated Passenger Domain Stalling as a Structural Probe of Autotransporter Outer Membrane Secretio

pp.：  278 – 298

Chapter 9: Strategies for the Thermodynamic Characterization of Linked Binding/Local Folding Reactions Within the Native Stat

pp.：  298 – 328

Chapter 10: Fluorescence-Detected Sedimentation in Dilute and Highly Concentrated Solutions

pp.：  328 – 350

Author Index

pp.：  350 – 362

Subject Index

pp.：  362 – 370

Color plate

pp.：  370 – 378

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