Clusterin, Part B ( Volume 105 )

Publication series :Volume 105

Author: Bettuzzi   Saverio;Pucci   Sabina  

Publisher: Elsevier Science‎

Publication year: 2009

E-ISBN: 9780123814302

P-ISBN(Paperback): 9780123814296

P-ISBN(Hardback):  9780123814296

Subject: R730.5 tumor therapeutics

Language: ENG

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Description

The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.

Chapter

Front Cover

pp.:  1 – 4

Advances in Cancer Research

pp.:  4 – 5

Copyright

pp.:  5 – 6

Contents

pp.:  6 – 10

Contributors

pp.:  10 – 12

Chapter 1: Clusterin (CLU) and Prostate Cancer

pp.:  12 – 32

Chapter 2: The Role of Clusterin (CLU) in Malignant Transformation and Drug Resistance in Breast Carcinomas

pp.:  32 – 56

Chapter 3: CLU and Colon Cancer. The Dual Face of CLU: From Normal to Malignant Phenotype

pp.:  56 – 74

Chapter 4: Clusterin (CLU) and Lung Cancer

pp.:  74 – 88

Chapter 5: Clusterin and Chemoresistance

pp.:  88 – 104

Chapter 6: CLU "In and Out": Looking for a Link

pp.:  104 – 126

Chapter 7: Regulation of CLU Gene Expression by Oncogenes and Epigenetic Factors: Implications for Tumorigenesis

pp.:  126 – 144

Chapter 8: Conclusions and Perspectives

pp.:  144 – 162

Index

pp.:  162 – 166

Color Plate

pp.:  166 – 168

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