Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors
( Volume 95 )
Publication series ：Volume 95
Publisher： Elsevier Science
Publication year： 2010
E-ISBN: 9780123813275
P-ISBN(Paperback): 9780123813268
P-ISBN(Hardback): 9780123813268
Subject： Q189 Neurobiology;R741 Neurology
Language： ENG
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Description
Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson’s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson’s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.
- Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors
- Preclinical models in COMT inhibitor devlopment
- Transgenic COMT mice – latest information summarized
- Chemistry of COMT inhibitors and their design with molecular modelling
- COMT gene and its regulation and relation to dopamine related diseases
- Role of cofactor SAM regulation in relation to homocysteine
- Nonclinical and clinical safety of COMT inhibitors summarized
- Future prospects of COMT inhibitors in Parkinson’s disease